Sarah Silverman

Sarah Silverman is known for breaking taboos in her comedy. Her new off-Broadway musical The Bedwetter, adapted from her 2010 memoir of the same name, centers on the most humiliating part of her childhood: wetting the bed every night until she was about 16.

September 11, AIDS, the Holocaust — comic and actress Sarah Silverman has repeatedly proved that practically nothing need be off limits in a joke. Take the title of her Off-Broadway show, which later became a film: Jesus Is Magic. Or the music video, available on her Comedy Central show's blog, of "The Doodie Song."

Silverman has appeared in films including School of Rock and There's Something About Mary and she was a member of the Saturday Night Live ensemble in the early '90s.

Susan Silverman, on her sister comic Sarah Silverman, growing up secular Jewish and becoming a rabbi, adopting two Ethiopian boys, and how she was affected by the death of a sibling when she was very young.